Description
Basic Info.
Model NO.
CAS 223673-61-8
Powder
Yes
Customized
Customized
Certification
GMP, ISO 9001, USP, BP, Ep
Suitable for
Elderly, Children, Adult
State
Solid
Purity
>99%
CAS
223673-61-8
Appearance
off-White Crystalline Powder
Mf
C21h24n4o2s
Test
HPLC
Storage
Cool Dry Place
Shelf Life
2 Years Proper Storage
Application
Pharmaceutical Intermediates
Trademark
ERRASON
Transport Package
1kg Per Foil Bag, 20kg Per Drum
Specification
99%
Origin
Nanjing
HS Code
29335990
Product Description
High Purity Best Price Mirabegron with CAS 223673-61-8 Mirabegron Powder
Mirabegron is for the treatment of urgency, urinary frequency, and urinary urge urinary incontinence associated with overactive bladder (OAB). Mirabegron is synthesized by coupling 4-nitrophenethyl amine to (R)-2-hydroxy-2-phenylacetic acid. The resulting amide is reduced to an amine. The nitro group is then reduced and the resulting is coupled to 2-(2-aminothiazol-4-yl) acetic acid to give mirabegron. Mirabegron has an EC50 of 22 nM (intrinsic activity=0.8) for β3-AR with no detectable activity for β1- andβ2-AR (EC50>10,000 nM). In an anesthetized rat rhythmic bladder contraction model in which bladder contractions are induced by saline, mirabegron at 3 mg/kg iv decreased the frequency of rhythmic bladder contraction without suppressing contraction amplitude. These data suggest that the activation of β3-AR increases bladder capacity without influencing the frequency of bladder contraction.
Function and Application
1.Mirabegron is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM.
2.Uses for A potent bladder relaxant compound
3.Uses for Potent bladder relaxant and reagent for diabetes remedy.;Labeled Mirabegron, intended for use as an internal standard for the quantification of Mirabegron by GC- or LC-mass spectrometry.
