Description
What is Levodopa?
Levodopa is a naturally occurring dietary supplement and psychoactive drug found in certain kinds of herbs. The most common plant source of Levodopa marketed in this manner is Stizolobium cochinchin ensis (Lour) and Mucuna Pruriens. Some animals including humans make it via biosynthesis from the amino acid L-tyrosine. L-DOPA is synthesized from the amino acid L-tyrosine in the mammalian body and brain, it is the precursor to the neurotransmitters dopamine, and collectively known as catecholamines. L-DOPA can be manufactured and in its pure form is sold as a psychoactive drug with the INN levodopa. Aside from its natural and essential biological role, L-DOPA is also used in the clinical treatment of Parkinson's disease and dopamine-responsive dystonia. It is a prescription drug in the US.
Function and Application
Used for the treatment of parkinsonian disorders and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system.
Dietary supplement and psychoactive drug.
| Product Name | Levodopa | ||
| Reference | USP standard | ||
| Test Items | Specifications | Results | |
| Appearance | White or almost white,crystalline powder | Almost white crystalline powder | |
| Identification | The infrared absorption spectrum is in accordance with the spectrum obtained with Levodopa RS. | Conform | |
| The retention time of the major peak from the Sample solution corresponds to that of the standard solution,as obtained in the test for Assay. | Conform | ||
| Loss on drying | ≤0.5% | 0.1% | |
| Residue on ignition | ≤0.1% | <0.1% | |
| Specific rotation | -160° to-167° | -161° | |
| Related substances (HPLC) | USP impurity A≤0.1% | <RL(RL:0.03%) | |
| L-Tyrosine≤0.1% | <RL(RL:0.03%) | ||
| USP impurity B≤0.5% | <LOD(LOD:0.004%) | ||
| L-Veratrylglycine≤0.1% | <LOD(LOD:0.005%) | ||
| Any individual unspecified impurity≤0.1% | <RL(RL:0.03%) | ||
| Total impurities≤1.1% | <RL | ||
| Assay (HPLC) | 98.0%~102.0% (calculated on dried basis) | 99.2% | |
| Residual solvents(GC) | Ethanol≤5000ppm | <LOD(LOD:75ppm) | |
| Conclusion | Complies with USP standard | ||
