Description
INTRODUCTION
What is Niclosamide?
Niclosamide is a teniacide in the anthelmintic family especially effective against cestodes that infect humans. It is also used as a piscicide. It is stressed that while antihelmintics are a drug family used to treat worm infections, Niclosamide is used specifically to treat tapeworms and is not effective against other worms such as pinworms or roundworms. It is a chewable tablet taken orally, dosage depending on type of worm and patient's age and/or weight. Niclosamide molecules are lethal to tapeworms upon contact.
FUNCTION
Function And Application of Niclosamide
Niclosamide is not easy to absorb orally, maintains a high concentration in the intestines, kills the head and near
segments of the aphids, and is clinically used to expel beef aphids, pork aphids and short-shelled aphids, which are
more effective than betel nut and pumpkin seeds. It is also used as a molluscicide. It can kill snails and cercariae
cercariae and edulis at a concentration of 0.2 to 0.5 parts per million. The dosage is 1 g/m2. This product is harmless
to warm-blooded animals and plants, but only to fish. This product can also be used as a coating agent for application
to the skin before launching to prevent acute schistosomiasis infection and rice dermatitis. (Niclosamide is included
in the WHO Essential Medicines List for use when praziquantel treatment is ineffective.
| Appearance | Yellowish fine crystals | Yellowish fine crystals |
| Assay | 98%-101% | 99.29% |
| Identity | Positive | Positive |
| 5-chlorosalicyclic acid | ≤60 ppm | Conforms |
| 2-chloro-4-nitroaniline | ≤100 ppm | Conforms |
| Chlorides | ≤500 ppm | Conforms |
| Related substances | ≤0.2% | Conforms |
| Melting point | 227ºC-232ºC | 229ºC-229.6ºC |
| Sulphated ash | ≤0.1% | 0.05% |
| Loss on drying | ≤0.5% | 0.23% |
