Tolvaptan (INN), also known as OPC-41061, is a selective, competitive vasopressin receptor 2 antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).
White to off-white crystalline powder
Off-white crystalline powder
Sparingly soluble in methanol, practically insoluble in water.
1) The infrared absorption spectrum is in accordance with the spectrum obtained with Tolvaptan reference standard.
2) The retention time of the major peak in the chromatogram obtained with test solution is in accordance with that in the chromatogram obtained with standard solution as Assay test.
The XRPD spectrum of the sample is in accordance with the spectrum obtained with Tolvaptan RS