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  4. Nevirapine CAS 129618-40-2
  • Nevirapine CAS 129618-40-2
  • Nevirapine CAS 129618-40-2
  • Nevirapine CAS 129618-40-2
  • Nevirapine CAS 129618-40-2
Nevirapine CAS 129618-40-2 Nevirapine CAS 129618-40-2 Nevirapine CAS 129618-40-2 Nevirapine CAS 129618-40-2

Nevirapine CAS 129618-40-2

  • Product Item:CAS 129618-40-2
  • CAS 129618-40-2
  • MF:C15H14N4O
  • Description:Off-white, odorless, crystalline powder
  • Assay:99.8%
  • Nevirapine  , 129618-40-2  , C15H14N4O  , chemical  , drugs
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    Description

    What is Nevirapine ?

    Nevirapine is a non nucleoside reverse transcriptase inhibitor (Non-Nucleoside Reverse Transcriptase Inhibitor, NNRTI) of HIV-1. Nevirapine was directly linked to the reverse transcriptase of HIV-1 and blocked the RNA dependent and DNA dependent DNA polymerase activity by breaking the catalytic end of the enzyme.

    Function and Application 
    Nevirapine could prevent mother to child transmission of H IV -1 in pregnant women who did not use antiretroviral therapy during childbirth. Nevirapine can be used alone to prevent mother to child transmission.

    Product Name Nevirapine
    Reference USP
    Test Items Specifications Results
    Characters Description White to off-white, odorless to nearly odorless, crystalline powder. Off-white, odorless, crystalline powder
    Solubility Slightly soluble in alcohol and in methanol, practically insoluble in water. Conform
    Identification A: The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay. Conform
    B: Infrared absorption spectrophotometry: corresponds to the reference standard. Conform
    Water(KF) ≤0.2% <0.1%
    Residue on ignition ≤0.1% <0.1%
    Heavy metals ≤0.001% <0.001%
    Related substances (HPLC) **lmpurity A≤0.2% N.D
    **lmpurity B≤0.2% <LOQ(LOQ:0.04%)
    **lmpurity C≤0.2% <LOQ(LOQ:0.04%)
    Any other individual unspecified impurity≤0.1% 0.07%
    Total impurities≤0.6% 0.07%
    Assay (HPLC) 98.0 %~102.0 % (calculated on anhydrous basis) 99.8%
    Residual solvents (GC) Ethanol≤3000ppm N.D
    Conclusion Complies with USP

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