Nevirapine is a non nucleoside reverse transcriptase inhibitor (Non-Nucleoside Reverse Transcriptase Inhibitor, NNRTI) of HIV-1. Nevirapine was directly linked to the reverse transcriptase of HIV-1 and blocked the RNA dependent and DNA dependent DNA polymerase activity by breaking the catalytic end of the enzyme.
Function and Application
Nevirapine could prevent mother to child transmission of H IV -1 in pregnant women who did not use antiretroviral therapy during childbirth. Nevirapine can be used alone to prevent mother to child transmission.
White to off-white, odorless to nearly odorless, crystalline powder.
Off-white, odorless, crystalline powder
Slightly soluble in alcohol and in methanol, practically insoluble in water.
A: The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay.
B: Infrared absorption spectrophotometry: corresponds to the reference standard.