Description
INTRODUCTION
Cytidylate, also known as 5'-cytidylic acid or simply cytidylate, and abbreviated CMP, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid with the nucleoside cytidine. CMP consists of the phosphate group, the pentose sugar ribose, and the nucleobase cytosine; hence, a ribonucleoside monophosphate. As a substituent it takes the form of the prefix cytidylyl.
USAGE
1. Cytidine 5′-monophosphate (CMP) is used as a substrate of uridine monophosphate (UMP)/cytidine monophosphate (CMP) kinase (EC 2.7.4.4) to form CDP which upon phosphorylation to CTP supports DNA and RNA biosynthesis.
2. This product is used as raw material intermediates for the production of nucleotide drugs and food additives, such as raw materials for the synthesis of CTP PolyIC ara-c DDC cdp-choline, and mixed with other nucleotides for health care products and food additives (such as baby milk powder).
| PRODUCT NAME: 5'-Cytidine Monophosphate Free Acid(CMP) | |||
| MOLECULE FORMULA | C9H14N3O8P | NET WEIGHT | 250kg |
| MOLECULE WEIGHT | 323.20 | TESTING BASED ON | Costumer requirement |
| Description: White or almost white crystalline powder | |||
| Physicochemical Norms | |||
| Testing Item | Unit | Standard | Result |
| Appearance | / | White or almost white crystalline powder | Confirmed |
| Identity | Pass identification test | Confirmed | |
| A 250/260 | / | 0.41-0.49 | 0.47 |
| A 280/260 | / | 2.00-2.17 | 2.05 |
| Assay on dry basis HPLC | % | 98.0-102.0 | 100.3 |
| Solubility | Slightly soluble in water and practically | Confirmed | |
| insoluble in alcohol | |||
| Clarity and color of solution | Colorless and almost clear | Confirmed | |
| Moisture | % | Max 6.0 | 2.7 |
| pH(1%solution) | / | 2.0~3.5 | 3.04 |
| Transmittance (1%solution) | % | Min.95 | 95.7 |
| Other decomposed substances of nucleic acid | Pass Pharmacopeia test | Confirmed | |
| Heavy metal (as Pb) | mg/kg | Max 10 | <10 |
| Lead (Pb) | mg/kg | Max 1.0 | <1.0 |
| Arsenic (As) | mg/kg | Max 1.0 | <1.0 |
| Cadmium (Cd) | mg/kg | Max 0.1 | <0.1 |
| Mercury (Hg) | mg/kg | Max 0.5 | <0.5 |
| Ethanol | mg/kg | Max 100 | <100 |
| Bacteriological Norms | |||
| Testing Item | Unit | Standard | Result |
| Total aerobic microbial count | cfu/g | Max. 1000 | <10 |
| Yeast & Moulds | cfu/g | Max. 30 | <10 |
| Colifbrms-E.coli | /log | Absent | Absent |
| Salmonella | /100g | Absent | Absent |
| Staphylococcus Aureus+ | /g | Absent | Absent |
| Listeria | /25g | Absent | Absent |
| Enterobacteria | /(3x5)g | Absent | Absent |
| E. sakazakii | /(3xl5)g | Absent | Absent |
| CONCLUSION: OK/PASS | |||
| Storage/Stabiiity: Stable at room temperature when stored in tightly closed container, protected from humidity. | |||
