Description
INTRODUCTION
Darunavir is a new kind of used for AIDS treatment of peptide antiretroviral protease inhibitors, is the 6 kinds of protease inhibitors (ShaKui that wei, the wei, indene that wei, naphthalene than the wey, dworkin that wei and ABT378 / r) in the living creature exploitation degree is the highest, by blocking from the infected host cell surface to release the new, the formation process of mature virus particles, suppress the virus protease and work. When using this product for a long time, often can reduce HIV carriers in the blood, increase the CD4 cell count, reduce the chance of HIV infection, improve the quality of life, prolong life. Suitable for infected with the AIDS virus but not existing antiretroviral drugs, curative effect of adults, the drug must be with low dose, the wei or other antiretroviral agents used in combination, in order to improve effectiveness.
Function:
Darunavir (brand name Prezista, formerly known as TMC114) is a protease inhibitor medication used to treat HIV infection. Darunavir is an OARAC recommended treatment option for treatment-naïve and treatment-experienced adults and adolescents.
Darunavir is a new kind of used for AIDS treatment of peptide antiretroviral protease inhibitors, is the 6 kinds of protease inhibitors (ShaKui that wei, the wei, indene that wei, naphthalene than the wey, dworkin that wei and ABT378 / r) in the living creature exploitation degree is the highest, by blocking from the infected host cell surface to release the new, the formation process of mature virus particles, suppress the virus protease and work. When using this product for a long time, often can reduce HIV carriers in the blood, increase the CD4 cell count, reduce the chance of HIV infection, improve the quality of life, prolong life. Suitable for infected with the AIDS virus but not existing antiretroviral drugs, curative effect of adults, the drug must be with low dose, the wei or other antiretroviral agents used in combination, in order to improve effectiveness.
Function:
Darunavir (brand name Prezista, formerly known as TMC114) is a protease inhibitor medication used to treat HIV infection. Darunavir is an OARAC recommended treatment option for treatment-naïve and treatment-experienced adults and adolescents.
| PARAMETER | SPECIFICATION | RESULTS | CONCLUSION |
| 1. Appearance | White or off-white crystalline powder | White crystalline powder | Complies |
| 2. Solubility | Soluble in DMSO, slightly soluble in water | Soluble in DMSO, slightly soluble in water | Complies |
| 3. Melting point | 70-76ºC | 74-75ºC | Complies |
| 4. Identification | 1H NMR | Conform | Complies |
| 5. Water Value | ≤0.5% | 0.20% | Complies |
| 6. Related Substances | Max single impurity ≤ 0.1% | Max single impurity 0.05% | Complies |
| Total impurities - ≤ 0.5% | Total impurities 0.1% | ||
| 7.Organic residual solvents | Ethanol ≤ 0.3% | Ethanol 0.1% | Complies |
| 8.Residue on ignition | ≤0.1% | 0.10% | Complies |
| 9. Heavy metal | ≤20ppm | <20ppm | Complies |
| 10. Assay | ≥98.5% | 99.50% | Complies |
| CONCLUSION | Qualified | ||
