Fosfomycin tromethamine is a bactericidal phosphonic acid derivative which acts primarily by inhibiting bacterial cell wall (peptidoglycan) synthesis. It has antibacterial activity against many pathogenic and opportunistic Gram-positive and Gram-negative bacteria isolated from patients with lower urinary tract infections (UTI). According to conventional in vitro susceptibility tests, fosfomycin has good activity against Escherichia coli, Staphylococcus aureus, and Serratia, Klebsiella, Citrobacter, Enterococcus and Enterobacter spp. Minimum inhibitory concentrations active against 90% of isolates (MIC90 values) for some other important pathogens are relatively high, but are well within the urinary concentrations of fosfomycin achieved during treatment with the drug.
Function and Application
Fosfomycin Trometamol for the treatment of acute simple lower urinary tract infections caused by sensitive bacteria (eg acute cystitis, acute exacerbation of chronic cystitis, acute urethral urethral syndrome, non-specific urethritis, asymptomatic bacteriuria during pregnancy, after surgery Urinary tract infections) and prevention of surgical infections caused by urinary tract infections and transurethral diagnostic procedures.