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  4. Torsemide CAS 56211-40-6
  • Torsemide CAS 56211-40-6
  • Torsemide CAS 56211-40-6
  • Torsemide CAS 56211-40-6
  • Torsemide CAS 56211-40-6
Torsemide CAS 56211-40-6 Torsemide CAS 56211-40-6 Torsemide CAS 56211-40-6 Torsemide CAS 56211-40-6

Torsemide CAS 56211-40-6

  • Product Item:CAS 56211-40-6
  • CAS 56211-40-6
  • MF:C16H20N4O3S
  • Appearance:Off-white crystalline powder
  • Assay:99.9%
  • Torsemide  , 56211-40-6  , chemical  , drugs  , C16H20N4O3S
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    Description

    Usage:

    Torasemide is a novel loop diuretic launched in 1993 after a 12-year gap from the last diuretic introduction. It is indicated for the treatment of hypertension and edema associated with chronic congestive heart failure, renal disease and hepatic cirrhosis. Torasemide exerts its major diuretic activity on the thick ascending limb of the Henle's loop to promote rapid and marked excretion of water, Na+, Cl-, and to a lesser extent,K+ and Ca2+. Compared with other loop diuretics such as furosemide, torasemide has a stronger antihypertensive action, a higher bioavailability, a longer duration of action that is independent of the renal function, and has no side effects such as paradoxical antidiuresis.

    Product name Torsemide
    Reference USP
    TEST SPECIFICATION RESULT
    Appearance White or off-white crystalline powder Off-white crystalline powder
    Identification The IR spectrum of the substance corresponds to that of the reference standard. Conforms
    The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation,as obtained in the Assay Conforms
    Water ≤1.0% 0.1%
    Residue on ignition ≤0.1% <0.1%
    Assay (HPLC) 98.0~102.0%(calculated on anhydrous basis) 99.9%
    Related substances(HPLC) Impurity A≤0.5% <RL(RL=0.05%)
    Impurity C≤0.2% <RL(RL=0.05%)
    Impurity B≤0.3% <LOD(LOD=0.005%)
    Unspecified impurities≤0.10% <LOD(LOD=0.009%)
    The total of unspecified impurities≤0.20% <LOD
    Total impurities≤1.0% <RL
    Residual solvents(GC) Ethanol≤5000ppm <LOD(LOD=30ppm)
    Methanol≤3000ppm 266ppm
    Dichloromethane≤600ppm <LOD(LOD=60ppm)
    N,N-dimethylformamide≤880ppm <LOD(LOD=29ppm)
    Conclusion Complies with USP

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