Rosuvastatin calcium CAS 147098-20-2

Description

INTRODUCTION
Rosuvastatin, one of the two new statins launched for the treatment of hypercholesterolemia, has high hepato-selectivity and more potent inhibitory effect on HMG-CoA reductase than the previously marketed statins. In rat hepatocytes, it inhibits cholesterol biosynthesis with an IC50 of 1.12 nM, which is ~100-fold higher potency than pravastatin. Rosuvastatin is synthesized in a 12-step sequence, entailing the construction of a pyrimidinyl aldehyde intermediate in eight steps and subsequent introduction of the dihydroxyheptenoate side chain via Wittig reaction with a bketophosphorane reagent and stereoselective carbonyl reduction of the resultant enone.

FUNCTION:

A selective, competitive HMG-CoA reductase inhibitor. Antilipemic.

Product Name	Rosuvastatin calcium
Item	Specification	Testing result
Appearance	White or almost white crystalline powder	White crystalline powder
CAS#	147098-20-2	Conforms
Identify	Infrared absorption spectrum should be consistent with the standard spectrum	Associated with the standard spectrum
Water	NMT 3.0%	2.00%
Specific rotation	+16 - +20°	+18.5°
Calcium	3.5% - 4.5%	3.80%
Heavy metal	≤20ppm	Conforms
Single impurity	NMT 0.5%	0.40%
Total impurities	NMT 1.0%	0.80%
Purity	≥99.0%	99.20%
Conclusion	Conformed with EP standard

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